They are diurnal monkeys. Saki Monkeys live in the trees of the rainforests and only occasionally go onto the land. These Monkeys mostly move on all fours, sometimes running in an upright position on the hind legs over the branches and sometimes jumping long distances. When sleeping, they roll themselves up like a cat in the branches. Saki Monkeys are generally very shy, cautious animals.

Also, they live in family groups which consist of parents and their offspring, with mated pairs usually forming lifelong pair bonds.

Saki Monkeys are territorial monkeys, defending their territory in relation to other families. They know a set of communication possibilities. While shrill cries or bird-like twitter serves as a connection among family members, a loud roar serves to warn other animals off their territory.

Nevertheless, these monkeys are omnivores. They eat fruits, leaves, flowers, insects and small vertebrates, such as rodents and bats.